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KMID : 0928520010110040515
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Korean Journal of Lipidology
2001 Volume.11 No. 4 p.515 ~ p.525
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Study on the Mutation Screening of the Apolipoprotein CII Gene in Korean Hypertensives and the Association with Plasma Triglyceride Level
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Bae Joon-Seol
Kang Byung-Yong
Kim Ki-Tae
Shin Jung-Hee
Lee Chung-Choo
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Abstract
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Objective: Hypertension is a multifactorial disease. Both genetic and environmental factors have been implicated in its etiology. High level of plasma triglyceride was suggested a risk factor for the development of cardiovascular disease. Human apolipoprotein CII (apoCII) plays a important role in lipid metabolism, hydrolyzing triglycerides in plasma chylomicron and very low-density lipoprotein (VLDL). In addition, apoCII gene was linked with apoCI and apoE gene in chromosome 19. In this regard, apoCII gene has been proposed to be a candidate gene for cardiovascular disease.
Methods: The essential hypertensives were defined as having a blood pressure above 140/90 mmHg. We scanned all of four exons of apoCII gene in 94 Korean normotensives and 84 essential hypertensives by single-strand conformational polymorphism (SSCP) using polymerase chain reaction (PCR) with each specific primer.
Results and Conclusion: We found a G-24T polymorphism by SSCP. No significant difference was observed between normotensives and essential hypertensives in the distribution of allele and genotype frequencies of this polymorphism in the apoCII gene (p=0.187). However, because this polymorphism is highly polymorphic in our subjects, our results may provide additional information for linkage analysis and association study of disorders in lipid metabolism or cardiovascular disease.
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KEYWORD
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Hypertension, Hypertriglyceridemia, Mutation, Polymorphism
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